Colorado House of Representatives: Prior to the election, the House was identified as a chamber that had a highly likelihood of changing partisan control. The split of 33 Republicans and 32 Democrats meant that even one lost seat for Republicans would give Democrats the majority.
- Incumbent Republicans Marsha Looper and Amy Stephens faced off in a primary battle for House District 19. Stephens won, 7,458-5,068.
- District 35: Incumbent Democrat Joyce Foster retired, but in the wake of redistricting this race was not necessarily being "defended" by Democrats, as new rural parts of the district drastically changed the demographics. Republican Larry Crowder successfully picked up the seat.
- District 3: Incumbent Daniel Kagan (D) saw her safely Democratic district wash away with redistricting, but managed to defeat challenger Brian Watson (R), the owner of a local real estate investment company.
- District 34: Incumbent John Soper (D) retired due to term limits. This is a seat that Republicans attempted to pick up, but Jodina Widhalm (R) was defeated by Steve Lebsock (D).
- District 47: Keith Swerdfeger (R) retired, leaving a seat for Democrats to potentially pick up. However, Netto Charles Rodosevich (D) was defeated by Clarice Navarro-Ratzlaff (R) in the general election.
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