- District 3: Incumbent John Pinto (D), who had been in office for 34 years, faced a primary challenge from Matthew Tso. Tso was defeated.
- District 4: Incumbent George K. Munoz faced two primary challengers, Genevieve J. Jackson and Charles E. Rountree, and came out victorious.
- District 8: Incumbent Pete Campos (D) faced state house District 68 incumbent Thomas Garcia (D). Campos defeated Garcia in the primary on June 5.
- The Democratic primary in District 30 was one of the closest races in the state, and a winner was not officially declared until mid-July. Eventually, Clemente Sanchez was named the winner by 11 votes over his niece, Maxine R. Velasquez.
- District 33: Incumbent Republicans Bill Burt and Rod Adair were thrust into the same district via the redistricting process. However, after initially declaring to run, Adair withdrew in advance of the primary.
- District 35: Incumbent John Arthur Smith (D) was challenged by Larry P. Martinez in the Democratic primary. Martinez was defeated.
- District 39: Incumbent Phil A. Griego (D) successfully fended off primary challenges from Nicole Castellano and Jack Sullivan.
- District 66: Incumbent Dennis Kintigh was defeated by incumbent Bob Wooley in the Republican primary. No Democrats filed to run in the 66th District, leaving Wooley unopposed in his re-election bid on November 6.
- In District 70, Richard D. Vigil upset incumbent Tomas E. Salazar in the Democratic primary. Vigil ran unopposed in the general election.
- District 17: In the 2008 Democratic primary, Timothy M. Keller defeated then-incumbent Shannon Robinson in a rough campaign. In 2012, Robinson vowed to defeat Keller, but this time, as a Republican. The two faced off in the general election on November 6, but Keller successfully kept his seat.
- District 29: Incumbent Michael Sanchez (D) defeated state house District 7 incumbent David Chavez (R) in the general election. The race was a rematch of a 2000 state senate race, won by Sanchez. Republican-backed PACs spent heavily to defeat Sanchez.
- District 32: Money poured in to help Tea Party challenger Cliff R. Pirtle defeat longtime incumbent Timothy Z. Jennings (D). Jennings was a popular moderate Democrat in a generally conservative district, but it was not enough to overcome Jennings, who won the seat.
- District 12: Incumbent Ernest Chavez (D) defeated challenger Clyde Wheeler for the third consecutive general election.
- District 15: Firefighter Emily A. Kane (D) fought a tough battle against attorney Christopher T. Saucedo (R) who had strong backing from his party. Kane won.
- District 36: Incumbent Andrew Nunez (I) was formerly a Democrat, but jumped ship this election cycle. He faced LULAC state director Phillip M. Archuleta (D) and restaurateur Mike A. Tellez (R). Democrat Archuleta won.
<ref> tags exist, but no
<references/> tag was found